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Soliciting Material Pursuant to § 240.14a-12

Cytokinetics, Incorporated

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Important Notice Regarding the Availability of Proxy Materials for the 2020 Annual Meeting  of Stockholders to be held on May 13, 2020, for Cytokinetics, Incorporated  This communication presents only an overview of the more complete proxy materials that are available to you on the Internet. We  encourage you to access and review all of the important information contained in the proxy materials before voting. To view the  proxy statement and annual report, go to To submit your proxy while visiting this site, you will need  the 12 digit control number in the shaded gray box below.  Under new United States Securities and Exchange  Commission rules, proxy materials do not have  to be delivered in paper. Proxy materials can  be distributed by making them available on the  Internet. We have chosen to use these procedures  for our 2020 Annual Meeting and need YOUR  participation.  If you want to receive a paper or e-mail copy of  the proxy materials, you must request one. There  is no charge to you for requesting a copy. In order  to receive a paper package in time for this year’s  annual meeting, please make this request on or  before April 29, 2020.  For a Convenient Way to VIEW Proxy Materials  _ and _  VOTE Online go to:   Proxy Materials Available to View or Receive:  1. Proxy Statement 2. Annual Report  Printed materials may be requested by one of the following methods:   *E-MAIL   INTERNET  TELEPHONE  1-866-390-9954   * If requesting material by e-mail, please send  a blank e-mail with the 12 digit control number  (shaded gray box below) in the subject line. No  other requests, instructions or other inquiries  should be included with your e-mail requesting  material.   You must use the 12 digit control number  located in the shaded gray box below.  ACCOUNT NO.  SHARES  Company Notice of the 2020 Annual Meeting   Date: May 13, 2020  Time: 10:30 A.M. (PDT)  Place: 280 East Grand Avenue, South San Francisco, CA 94080  The purpose of the Annual Meeting is to take action on the following proposals:  The Board of Directors recommends a vote FOR the following:  1. Election of the Board of Directors’ nominees as Class I Directors each to serve for a three-year term and until their successors are duly elected  and qualified  Nominees 01 L. Patrick Gage, Ph.D. 02 Edward M. Kaye, M.D. 03 Wendell Wierenga, Ph.D.  The Board of Directors recommends a vote FOR the following proposals:  2. Approval of the Amended and Restated 2015 Employee Stock Purchase Plan to increase the number of authorized shares reserved for issuance  under the 2015 Employee Stock Purchase Plan by 500,000 shares  3. Ratification of the selection by the Audit Committee of the Board of Directors of Ernst & Young LLP as our independent registered public accounting  firm for the fiscal year ending December 31, 2020  4. Approval, on an advisory basis, of the compensation of the Company’s named executive officers, as disclosed in its Proxy Statement    See the reverse side of this notice to obtain proxy materials and voting instructions. You are receiving this communication because you Please make the request as instructed above on or before May 01, 2019 to facilitate timely delivery.