101 - Document - Document and Entity Information link:calculationLink link:presentationLink link:definitionLink 103 - Statement - Consolidated Balance Sheets link:calculationLink link:presentationLink link:definitionLink 104 - Statement - Consolidated Balance Sheets (Parenthetical) link:calculationLink link:presentationLink link:definitionLink 105 - Statement - Consolidated Statement of Operations and Comprehensive Income (Loss) link:calculationLink link:presentationLink link:definitionLink 106 - Statement - Consolidated Statements of Stockholders' Equity link:calculationLink link:presentationLink link:definitionLink 107 - Statement - Consolidated Statements of Stockholders' Equity (Parenthetical) link:calculationLink link:presentationLink link:definitionLink 108 - Statement - Consolidated Statements of Cash Flows link:calculationLink link:presentationLink link:definitionLink 109 - Disclosure - Organization and Significant Accounting Policies link:calculationLink link:presentationLink link:definitionLink 110 - Disclosure - Net Income (Loss) Per Share link:calculationLink link:presentationLink link:definitionLink 111 - Disclosure - Supplementary Cash Flow Data link:calculationLink link:presentationLink link:definitionLink 112 - Disclosure - Cash Equivalents and Investments link:calculationLink link:presentationLink link:definitionLink 113 - Disclosure - Fair Value Measurements link:calculationLink link:presentationLink link:definitionLink 114 - Disclosure - Balance Sheet Components link:calculationLink link:presentationLink link:definitionLink 115 - Disclosure - Related Parties and Related Party Transactions link:calculationLink link:presentationLink link:definitionLink 116 - Disclosure - Other Research and Development Revenue Arrangements Grants link:calculationLink link:presentationLink link:definitionLink 117 - Disclosure - Long-Term Debt link:calculationLink link:presentationLink link:definitionLink 118 - Disclosure - Commitments and Contingencies link:calculationLink link:presentationLink link:definitionLink 119 - Disclosure - Stockholders' Equity link:calculationLink link:presentationLink link:definitionLink 120 - Disclosure - Income Taxes link:calculationLink link:presentationLink link:definitionLink 121 - Disclosure - Interest and Other Income, Net link:calculationLink link:presentationLink link:definitionLink 122 - Disclosure - Quarterly Financial Data link:calculationLink link:presentationLink link:definitionLink 123 - Disclosure - Subsequent Events link:calculationLink link:presentationLink link:definitionLink 124 - Disclosure - Organization and Significant Accounting Policies (Policies) link:calculationLink link:presentationLink link:definitionLink 125 - Disclosure - Net Income (Loss) Per Share (Tables) link:calculationLink link:presentationLink link:definitionLink 126 - Disclosure - Supplementary Cash Flow Data (Tables) link:calculationLink link:presentationLink link:definitionLink 127 - Disclosure - Cash Equivalents and Investments (Tables) link:calculationLink link:presentationLink link:definitionLink 128 - Disclosure - Fair Value Measurements (Tables) link:calculationLink link:presentationLink link:definitionLink 129 - Disclosure - Balance Sheet Components (Tables) link:calculationLink link:presentationLink link:definitionLink 130 - Disclosure - Related Parties and Related Party Transactions (Tables) link:calculationLink link:presentationLink link:definitionLink 131 - Disclosure - Other Research and Development Revenue Arrangements Grants (Tables) link:calculationLink link:presentationLink link:definitionLink 132 - Disclosure - Long-Term Debt (Tables) link:calculationLink link:presentationLink link:definitionLink 133 - Disclosure - Commitments and Contingencies (Tables) link:calculationLink link:presentationLink link:definitionLink 134 - Disclosure - Stockholders' Equity (Tables) link:calculationLink link:presentationLink link:definitionLink 135 - Disclosure - Income Taxes (Tables) link:calculationLink link:presentationLink link:definitionLink 136 - Disclosure - Quarterly Financial Data (Tables) link:calculationLink link:presentationLink link:definitionLink 137 - Disclosure - Organization and Significant Accounting Policies - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 138 - Disclosure - Net Income (Loss) Per Share - Calculation of Basic and Diluted Net Income (Loss) Per Share (Detail) link:calculationLink link:presentationLink link:definitionLink 139 - Disclosure - Net Income (Loss) Per Share - Instruments Excluded from the Computation of Diluted Net Income (Loss) Per Share (Detail) link:calculationLink link:presentationLink link:definitionLink 140 - Disclosure - Supplementary Cash Flow Data - Supplemental Cash Flow Information (Detail) link:calculationLink link:presentationLink link:definitionLink 141 - Disclosure - Cash Equivalents and Investments - Amortized Cost and Fair Value of Cash Equivalents and Available for Sale Investments (Detail) link:calculationLink link:presentationLink link:definitionLink 142 - Disclosure - Cash Equivalents and Investments - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 143 - Disclosure - Cash Equivalents and Investments - Summary of Interest Income (Detail) link:calculationLink link:presentationLink link:definitionLink 144 - Disclosure - Fair Value Measurements - Summary of Financial Assets Measured at Fair Value on Recurring Basis (Detail) link:calculationLink link:presentationLink link:definitionLink 145 - Disclosure - Fair Value Measurements - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 146 - Disclosure - Balance Sheet Components - Summary of Property and Equipment Balances (Detail) link:calculationLink link:presentationLink link:definitionLink 147 - Disclosure - Balance Sheet Components - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 148 - Disclosure - Balance Sheet Components - Summary of Accrued Liabilities (Detail) link:calculationLink link:presentationLink link:definitionLink 149 - Disclosure - Related Parties and Related Party Transactions - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 150 - Disclosure - Related Parties and Related Party Transactions - Revenue from Related Party (Detail) link:calculationLink link:presentationLink link:definitionLink 151 - Disclosure - Related Parties and Related Party Transactions - Schedule of Arrangement Consideration under 2016 Amendment Related to CK-107 and Research (Detail) link:calculationLink link:presentationLink link:definitionLink 152 - Disclosure - Related Parties and Related Party Transactions - Schedule Represents Allocation of Arrangement Consideration, and Revenue Recognition (Detail) link:calculationLink link:presentationLink link:definitionLink 153 - Disclosure - Other Research and Development Revenue Arrangements Grants - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 154 - Disclosure - Other Research and Development Revenue Arrangements Grants - Summary of Total Grant Revenues (Detail) link:calculationLink link:presentationLink link:definitionLink 155 - Disclosure - Other Research and Development Revenue Arrangements Grants - Summary of Reimbursed Expenses (Detail) link:calculationLink link:presentationLink link:definitionLink 156 - Disclosure - Long-Term Debt - Schedule of Long Term Debt and Unamortized Debt Discount (Detail) link:calculationLink link:presentationLink link:definitionLink 157 - Disclosure - Long-Term Debt - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 158 - Disclosure - Long-Term Debt - Schedule of Future Minimum Payments under Loan (Detail) link:calculationLink link:presentationLink link:definitionLink 159 - Disclosure - Commitments and Contingencies - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 160 - Disclosure - Commitments and Contingencies - Rent Expense (Detail) link:calculationLink link:presentationLink link:definitionLink 161 - Disclosure - Commitments and Contingencies - Future Minimum Lease Payments under Noncancelable Operating Leases (Detail) link:calculationLink link:presentationLink link:definitionLink 162 - Disclosure - Commitments and Contingencies - Future Minimum Payments for Co-investment (Detail) link:calculationLink link:presentationLink link:definitionLink 163 - Disclosure - Stockholders' Equity - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 164 - Disclosure - Stockholders' Equity - Outstanding Warrants (Detail) link:calculationLink link:presentationLink link:definitionLink 165 - Disclosure - Stockholders' Equity - Summary of Equity Incentive Plan (Detail) link:calculationLink link:presentationLink link:definitionLink 166 - Disclosure - Stockholders' Equity - Summary of Restricted Stock Unit Activity (Detail) link:calculationLink link:presentationLink link:definitionLink 167 - Disclosure - Stockholders' Equity - Summary of Performance Stock Unit Activity (Detail) link:calculationLink link:presentationLink link:definitionLink 168 - Disclosure - Stockholders' Equity - Stock-Based Compensation Related to Stock Options, Restricted Stock Awards, Restricted Stock Unit, and Employee Stock Purchases (Detail) link:calculationLink link:presentationLink link:definitionLink 169 - Disclosure - Stockholders' Equity - Fair Value of Share-Based Payments was Estimated on Date of Grant Using Black-Scholes Option Pricing Model Based on Weighted Average Assumptions (Detail) link:calculationLink link:presentationLink link:definitionLink 170 - Disclosure - Income Taxes - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 171 - Disclosure - Income Taxes - Schedule of Components of Income (Loss) Before Taxes (Detail) link:calculationLink link:presentationLink link:definitionLink 172 - Disclosure - Income Taxes - Company Recorded Income Tax Provision (Detail) link:calculationLink link:presentationLink link:definitionLink 173 - Disclosure - Income Taxes - Company's Deferred Tax Assets and Liabilities (Detail) link:calculationLink link:presentationLink link:definitionLink 174 - Disclosure - Income Taxes - Company's Valuation and Qualifying Accounts (Detail) link:calculationLink link:presentationLink link:definitionLink 175 - Disclosure - Income Taxes - Reconciliation of Statutory Federal Income Tax Rate to Effective Tax Rate (Detail) link:calculationLink link:presentationLink link:definitionLink 176 - Disclosure - Income Taxes - Schedule of Activity Related to our Gross Unrecognized Tax Benefits (Detail) link:calculationLink link:presentationLink link:definitionLink 177 - Disclosure - Quarterly Financial Data - Summary of Quarterly Results (Detail) link:calculationLink link:presentationLink link:definitionLink 178 - Disclosure - Subsequent Events - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink